Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis

Background & Aims Bacterial infections (BI) affect the natural course of cirrhosis and were suggested to be a landmark event marking transition decompensated stage. Our specific aim was evaluate impact BI on history compensated cirrhosis. Methods We analyzed 858 patients with cirrhosis, evaluated for INCA trial (EudraCT 2013-001626-26) in 2 academic medical centers between February 2014 May 2019. Only previously disease included. They divided into 4 groups: without BI, 1st decompensation BI. Results 425 (median 61 [53-69] years) included final prospective analysis. At baseline, 257 (12 [4.7%] BI), whereas 168 presented their (42 [25.0%] BI). In who remained MELD scores similar those Patients first had higher than Amongst compensated, no influence transplant-free survival, concurrent significantly reduced survival as compared The development or during follow-up greater each these complications at baseline. Conclusions associated has worse By contrast, does not negatively